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Also known as mucocutaneous lymph node syndrome.

“It is a disease in which blood vessels throughout the body becomes inflamed”.

It is a rare disease occur in children below age of 5 years. Frequency is 124/100,000  but in japan it occurs as 124/100,000.

Boys are affected more than girls.

Pathogenesis

Autoimmune response of T-cells into vascular antigens.

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Signs and symptoms

  1. High and persistant fever for more than 5 days. Fever is not responsive to paracetamol and ibuprofen.
  2. Erythema of oral cavity, cracking of lips and “strawberry tongue”.
  3. Red eyes, bilateral non supporative conjunctivitis.
  4. Edema of limbs.
  5. Rashes in lips, palm, soles and genitals.
  6. Sore throat and diarrhea.

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Compilacations

Coronary arteries aneurysm, which leads to myocardial infarction and sudden death.

Lab diagnose

  1. Total blood count, normocytic anemia & thrombocytopenia.
  2. Elevated ESR.
  3. ECG shows ventricular dysfunctions and arrhythmia.
  4. Proteinuria on urine analysis.

treatment

  1. Intravenous immunoglobulins (IVIG).
  2. Aspirin therapy (aspirin is a rare recommendation for children, as it is associated with Reye’s syndrome)
  3. Corticosteroids may used when other treatment fails.

2 thoughts on “KAWASAKI DISEASE

  1. Noor Ali Shah says:

    I know about Kawasaki diseases symptoms. It is very useful post.

  2. Noor Ali Shah says:

    I learnt about Kawasaki diseases.It is very useful post.

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